Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Lineage-specific gene duplication and loss in human and great ape evolution

ABSTRACT: Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several hominoid lineages. Interspecies cDNA array-based comparative genomic hybridization was used to individually compare copy number variation for 39,711 cDNAs, representing 29,619 human genes, across five hominoid species, including human. We identified 1,005 genes, either as isolated genes or in clusters positionally biased toward rearrangement-prone genomic regions, that produced relative hybridization signals unique to one or more of the hominoid lineages. Measured as a function of the evolutionary age of each lineage, genes showing copy number expansions were most pronounced in human (134) and include a number of genes thought to be involved in the structure and function of the brain. This work represents, to our knowledge, the first genome-wide gene-based survey of gene duplication across hominoid species. The genes identified here likely represent a significant majority of the major gene copy number changes that have occurred over the past 15 million years of human and great ape evolution and are likely to underlie some of the key phenotypic characteristics that distinguish these species. A species experiment design type assays differences between distinct species. Using regression correlation, arrayCGH, acCGH

ORGANISM(S): Homo sapiens

SUBMITTER: Young Kim

PROVIDER: E-GEOD-3980 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Lineage-specific gene duplication and loss in human and great ape evolution.

Fortna Andrew A Kim Young Y MacLaren Erik E Marshall Kriste K Hahn Gretchen G Meltesen Lynne L Brenton Matthew M Hink Raquel R Burgers Sonya S Hernandez-Boussard Tina T Karimpour-Fard Anis A Glueck Deborah D McGavran Loris L Berry Rebecca R Pollack Jonathan J Sikela James M JM

PLoS biology 20040713 7

Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several hominoid lineages. Interspecies cDNA array-based comparative genomic hybridization was used to individually compare copy number variation for 39,711 cDNAs, representing 29,619 human gene ...[more]

PMID: 15252450

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Dataset Information

Lineage-specific gene duplication and loss in human and great ape evolution

Publications

Lineage-specific gene duplication and loss in human and great ape evolution.

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