Unknown,Transcriptomics,Genomics,Proteomics

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Micrometastasis primary tumors


ABSTRACT: Primary tumors from a series of breast cancer patients evaluated for the presence of tumor cells in bone marrow. Samples were taken at primary surgery, RNA isolated from fresh frozen tumors, amplified and hybridized to 42k cDNA arrays. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Computed

ORGANISM(S): Homo sapiens

SUBMITTER: Therese Sorlie 

PROVIDER: E-GEOD-3985 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer.

Naume Bjørn B   Zhao Xi X   Synnestvedt Marit M   Borgen Elin E   Russnes Hege Giercksky HG   Lingjaerde Ole Christian OC   Strømberg Maria M   Wiedswang Gro G   Kvalheim Gunnar G   Kåresen Rolf R   Nesland Jahn M JM   Børresen-Dale Anne-Lise AL   Sørlie Therese T  

Molecular oncology 20070404 2


Expression profiles of primary breast tumors were investigated in relation to disseminated tumor cells (DTCs) in bone marrow (BM) in order to increase our understanding of the dissemination process. Tumors were classified into five pre-defined molecular subtypes, and presence of DTC identified (at median 85 months follow-up) a subgroup of luminal A patients with particular poor outcome (p=0.008). This was not apparent for other tumor subtypes. Gene expression profiles associated with DTC and wit  ...[more]

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