Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Norman Lacayo
PROVIDER: E-GEOD-3986 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lacayo Norman J NJ Meshinchi Soheil S Kinnunen Paivi P Yu Ron R Wang Yan Y Stuber Christianna M CM Douglas Lorrie L Wahab Romina R Becton David L DL Weinstein Howard H Chang Myron N MN Willman Cheryl L CL Radich Jerald P JP Tibshirani Robert R Ravindranath Yaddanapudi Y Sikic Branimir I BI Dahl Gary V GV
Blood 20040713 9
Fms-like tyrosine kinase 3 (FLT3) mutations are associated with unfavorable outcomes in children with acute myeloid leukemia (AML). We used DNA microarrays to identify gene expression profiles related to FLT3 status and outcome in childhood AML. Among 81 diagnostic specimens, 36 had FLT3 mutations (FLT3-MUs), 24 with internal tandem duplications (ITDs) and 12 with activating loop mutations (ALMs). In addition, 8 of 19 specimens from patients with relapses had FLT3-MUs. Predictive analysis of mic ...[more]