Role of TAZ as mediator of Wnt signaling
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Silvio Bicciato
PROVIDER: E-GEOD-39907 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Role of TAZ as mediator of Wnt signaling.
Azzolin Luca L Zanconato Francesca F Bresolin Silvia S Forcato Mattia M Basso Giuseppe G Bicciato Silvio S Cordenonsi Michelangelo M Piccolo Stefano S
Cell 20121213 7
Wnt growth factors are fundamental regulators of cell fate, but how the Wnt signal is translated into biological responses is incompletely understood. Here, we report that TAZ, a biologically potent transcriptional coactivator, serves as a downstream element of the Wnt/β-catenin cascade. This function of TAZ is independent from its well-established role as mediator of Hippo signaling. In the absence of Wnt activity, the components of the β-catenin destruction complex--APC, Axin, and GSK3--are al ...[more]
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