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Role of TAZ as mediator of Wnt signaling (MII)

ABSTRACT: To investigate the role of TAZ downstream of APC and beta-catenin in mammary epithelial cells cells, we compared the expression profiles of MCF10-T1k (MII) cells transfected with siControl, siAPC, siAPC+siTAZ, sibeta-catenin, or sibeta-catenin+siTAZ. Keywords: expression profiling by array We collected RNA from MII cells transfected with siControl, siAPC, siAPC+siTAZ, sibeta-catenin, or sibeta-catenin+siTAZ. Cells were left untreated in normal culturing conditions before harvesting. Samples were then processed for total RNA extraction and hybridization on Affymetrix microarrays. Four biological replicas (A, B, C, D) were used for each of the 5 conditions (1: siControl, control cells; 2: siAPC cells; 3: siAPC+siTAZ cells; 4: sibeta-catenin (sibcat) cells; 5: sibeta-catenin+siTAZ) for a total of 20 samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Silvio Bicciato 

PROVIDER: E-GEOD-39902 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Wnt growth factors are fundamental regulators of cell fate, but how the Wnt signal is translated into biological responses is incompletely understood. Here, we report that TAZ, a biologically potent transcriptional coactivator, serves as a downstream element of the Wnt/β-catenin cascade. This function of TAZ is independent from its well-established role as mediator of Hippo signaling. In the absence of Wnt activity, the components of the β-catenin destruction complex--APC, Axin, and GSK3--are al  ...[more]

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