Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: jianguo tao
PROVIDER: E-GEOD-40019 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhang Xinwei X Zhao Xiaohong X Fiskus Warren W Lin Jianhong J Lwin Tint T Rao Rekha R Zhang Yizhuo Y Chan John C JC Fu Kai K Marquez Victor E VE Chen-Kiang Selina S Moscinski Lynn C LC Seto Edward E Dalton William S WS Wright Kenneth L KL Sotomayor Eduardo E Bhalla Kapil K Tao Jianguo J
Cancer cell 20121001 4
We investigated the transcriptional and epigenetic repression of miR-29 by MYC, HDAC3, and EZH2 in mantle cell lymphoma and other MYC-associated lymphomas. We demonstrate that miR-29 is repressed by MYC through a corepressor complex with HDAC3 and EZH2. MYC contributes to EZH2 upregulation via repression of the EZH2 targeting miR-26a, and EZH2 induces MYC via inhibition of the MYC targeting miR-494 to create positive feedback. Combined inhibition of HDAC3 and EZH2 cooperatively disrupted the MYC ...[more]