Unknown,Transcriptomics,Genomics,Proteomics

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Real-time quantitative PCR analysis of DZNep treated B cell Lymphoma cell line Jeko-1


ABSTRACT: Jeko-1 cells were culture with or without PRC2 inhibitor 3-deazaneplanocin A (DZNep)(1uM) for 72hrs. We used TaqManM-BM-. Human MicroRNA Array to quantitate miRNA expression profile regulated by PRC2. qPCR miRNA expression profiling.

ORGANISM(S): Homo sapiens

SUBMITTER: jianguo tao 

PROVIDER: E-GEOD-40019 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


We investigated the transcriptional and epigenetic repression of miR-29 by MYC, HDAC3, and EZH2 in mantle cell lymphoma and other MYC-associated lymphomas. We demonstrate that miR-29 is repressed by MYC through a corepressor complex with HDAC3 and EZH2. MYC contributes to EZH2 upregulation via repression of the EZH2 targeting miR-26a, and EZH2 induces MYC via inhibition of the MYC targeting miR-494 to create positive feedback. Combined inhibition of HDAC3 and EZH2 cooperatively disrupted the MYC  ...[more]

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