Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone


ABSTRACT: To explore the molecular pathways underlying thiazolidinediones effects on pancreatic islets in conditions mimicking normo- and hyperglycemia, apoptosis rate and transcriptional response to Pioglitazone at both physiological and supraphysiological glucose concentrations were evaluated. Adult rat islets were cultured at physiological (5.6 mM) and supraphysiological (23 mM) glucose concentrations in presence of 10 mM Pioglitazone or vehicle. RNA expression profiling was evaluated with the PancChip 13k cDNA microarray after 24-h, and expression results for some selected genes were validated by qRT-PCR.

ORGANISM(S): Mus musculus

SUBMITTER: Peter White 

PROVIDER: E-GEOD-40119 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2010-07-01 | E-GEOD-5360 | biostudies-arrayexpress
2014-08-27 | E-GEOD-60803 | biostudies-arrayexpress
2013-12-19 | E-GEOD-53454 | biostudies-arrayexpress
2013-02-05 | E-GEOD-39874 | biostudies-arrayexpress
2008-10-20 | E-GEOD-8873 | biostudies-arrayexpress
2012-05-31 | E-GEOD-38364 | biostudies-arrayexpress
2010-06-25 | E-GEOD-15140 | biostudies-arrayexpress
2013-09-21 | E-GEOD-51055 | biostudies-arrayexpress
2008-12-30 | E-GEOD-11257 | biostudies-arrayexpress
2012-05-10 | E-GEOD-16145 | biostudies-arrayexpress