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Human islets exposed to cytokines IL-1β and IFN-γ

ABSTRACT: In the context of T1 Diabetes, pro-inflammatory cytokines IL-1β and IFN-γ are known to contribute to β-cell apoptosis; The measurement of mRNA expression following β-cell exposure to these cytokines gives a picture of the changes in gene expression characterizing the path to β-cell dysfunction and death. Human islets were isolated and exposed (or not) to IL-1β and IFN-γ. The samples were collected at various time points for profiling with Affymetrix arrays. These measurements were performed three times.

ORGANISM(S): Homo sapiens

SUBMITTER: Miguel Lopes

PROVIDER: E-GEOD-53454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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