Polarized T84 Cells Response to H. pylori infection
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Douglas Merrell
PROVIDER: E-GEOD-4012 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers.
El-Etr Sahar H SH Mueller Anne A Tompkins Lucy S LS Falkow Stanley S Merrell D Scott DS
The Journal of infectious diseases 20040909 8
To extend our knowledge of host-cell targets of Helicobacter pylori, we characterized the interaction between H. pylori and human T84 epithelial cell polarized monolayers. Transcriptional analysis by use of human microarrays and a panel of isogenic H. pylori mutants revealed distinct responses to infection. Of the 670 genes whose expression changed, most (92%) required the cag pathogenicity island (PAI). Although altered expression of many genes was dependent on CagA (80% of the PAI-dependent ge ...[more]
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