Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcriptional profile Lactobacillus plantarum WCFS1 : p-coumaric acid (p-CA) treated cells

ABSTRACT: Whole genome transcriptional profiling was used to characterize the response of Lactobacillus plantarum WCFS1 human isolate during challenge with p-coumaric acid (p-CA). Twelve independent experiments were performed and mixed at random in groups of four for total of three RNA samples. The transcriptional profile reveals a massive induction of genes involved in stress resistance and detoxification-related functions and a global shutdown of growth-associated processes. Biological triplicates: untreated cells: Control vs. p-coumaric treated cells: Experimental

ORGANISM(S): Lactobacillus plantarum

SUBMITTER: Felix Lopez de Felipe

PROVIDER: E-GEOD-40126 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide transcriptomic responses of a human isolate of Lactobacillus plantarum exposed to p-coumaric acid stress.

Reverón Inés I de Las Rivas Blanca B Muñoz Rosario R López de Felipe Félix F

Molecular nutrition & food research 20121015 12

<h4>Scope</h4>To advance knowledge of the stress tolerance mechanisms of a probiotic Lactobacillus plantarum strain to dietary hydroxycinnamic acids and the role of gut commensal microorganisms in the bioactivation of polyphenols.<h4>Methods and results</h4>To understand how gut commensal microorganisms tolerate toxicity of hydroxycinnamic acids and bioactivate these compounds, we used whole genome transcriptional profiling to characterize the response of a L. plantarum human isolate during chal ...[more]

PMID: 23065750

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Dataset Information

Transcriptional profile Lactobacillus plantarum WCFS1 : p-coumaric acid (p-CA) treated cells

Publications

Genome-wide transcriptomic responses of a human isolate of Lactobacillus plantarum exposed to p-coumaric acid stress.

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