Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kate Rubins
PROVIDER: E-GEOD-4013 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rubins Kathleen H KH Hensley Lisa E LE Jahrling Peter B PB Whitney Adeline R AR Geisbert Thomas W TW Huggins John W JW Owen Art A Leduc James W JW Brown Patrick O PO Relman David A DA
Proceedings of the National Academy of Sciences of the United States of America 20041011 42
Smallpox has played an unparalleled role in human history and remains a significant potential threat to public health. Despite the historical significance of this disease, we know little about the underlying pathophysiology or the virulence mechanisms of the causative agent, variola virus. To improve our understanding of variola pathogenesis and variola-host interactions, we examined the molecular and cellular features of hemorrhagic smallpox in cynomolgus macaques. We used cDNA microarrays to a ...[more]