Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: johann Soret
PROVIDER: E-GEOD-40197 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
RNA (New York, N.Y.) 20131023 12
Spinal muscular atrophy is a neuromuscular disease resulting from mutations in the SMN1 gene, which encodes the survival motor neuron (SMN) protein. SMN is part of a large complex that is essential for the biogenesis of spliceosomal small nuclear RNPs. SMN also colocalizes with mRNAs in granules that are actively transported in neuronal processes, supporting the hypothesis that SMN is involved in axonal trafficking of mRNPs. Here, we have performed a genome-wide analysis of RNAs present in compl ...[more]