Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Neuron
SUBMITTER: Mario Oroshi
LAB HEAD: Matthias Mann
PROVIDER: PXD021360 | Pride | 2021-01-26
REPOSITORIES: Pride
Items per page: 1 - 5 of 15 |
Nature communications 20210224 1
Gene expression requires tight coordination of the molecular machineries that mediate transcription and splicing. While the interplay between transcription kinetics and spliceosome fidelity has been investigated before, less is known about mechanisms regulating the assembly of the spliceosomal machinery in response to transcription changes. Here, we report an association of the Smn complex, which mediates spliceosomal snRNP biogenesis, with the 7SK complex involved in transcriptional regulation. ...[more]