Unknown,Transcriptomics,Genomics,Proteomics

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Hydroxymethylation at gene regulatory regions directs stem cell commitment during erythropoiesis


ABSTRACT: CD34 positive hematopoietic stem cells were differentiated into erythroid lineage. Next generation sequencing (NGS) of 5hmC affinity pulldown and RNAseq were performed in four time point of different stages of erythroid differentiation. 4 RNA-Seq Samples (d0, d3, d7 and d10); 4 affinity-pulldown (d0, d3, d7 and d10), and 4 input samples (d0, d3, d7 and d10).

ORGANISM(S): Homo sapiens

SUBMITTER: Jozef Madzo 

PROVIDER: E-GEOD-40243 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Hematopoietic stem cell differentiation involves the silencing of self-renewal genes and induction of a specific transcriptional program. Identification of multiple covalent cytosine modifications raises the question of how these derivatized bases influence stem cell commitment. Using a replicative primary human hematopoietic stem/progenitor cell differentiation system, we demonstrate dynamic changes of 5-hydroxymethylcytosine (5-hmC) during stem cell commitment and differentiation to the erythr  ...[more]

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