Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jozef Madzo
PROVIDER: E-GEOD-40243 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Madzo Jozef J Liu Hui H Rodriguez Alexis A Vasanthakumar Aparna A Sundaravel Sriram S Caces Donne Bennett D DBD Looney Timothy J TJ Zhang Li L Lepore Janet B JB Macrae Trisha T Duszynski Robert R Shih Alan H AH Song Chun-Xiao CX Yu Miao M Yu Yiting Y Grossman Robert R Raumann Brigitte B Verma Amit A He Chuan C Levine Ross L RL Lavelle Don D Lahn Bruce T BT Wickrema Amittha A Godley Lucy A LA
Cell reports 20131227 1
Hematopoietic stem cell differentiation involves the silencing of self-renewal genes and induction of a specific transcriptional program. Identification of multiple covalent cytosine modifications raises the question of how these derivatized bases influence stem cell commitment. Using a replicative primary human hematopoietic stem/progenitor cell differentiation system, we demonstrate dynamic changes of 5-hydroxymethylcytosine (5-hmC) during stem cell commitment and differentiation to the erythr ...[more]