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Transcription profiling time series of the cAMP-induced decidualization of human endometrial stromal cells

ABSTRACT: Timecourse of cAMP-induced decidualization of endometrial stromal cells.

Note that files GSM5962.txt and GSM5965.txt as imported from GEO are identical.

ORGANISM(S): Homo sapiens

SUBMITTER: Said Talbi

PROVIDER: E-GEOD-403 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Activation of the protein kinase A pathway in human endometrial stromal cells reveals sequential categorical gene regulation.

Tierney Emily P EP Tulac Suzana S Huang Se-Te Joseph ST Giudice Linda C LC

Physiological genomics 20031216 1

Decidualization of endometrial stromal cells is a prerequisite for human implantation and occurs in vivo in response to progesterone and involves activation of the protein kinase A (PKA) pathway. The objective of this study was to determine the molecular signatures and patterns of gene expression during stimulation of this pathway with an analog of cAMP. Endometrial stromal cells from two subjects were treated with or without 8-Br-cAMP (1 mM) for 0, 2, 12, 24, 36, and 48 h and were processed for ...[more]

PMID: 14532334

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