Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Qing Lu
PROVIDER: E-GEOD-40431 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Weng Qinjie Q Chen Ying Y Wang Haibo H Xu Xiaomei X Yang Bo B He Qiaojun Q Shou Weinian W Chen Yan Y Higashi Yujiro Y van den Berghe Veronique V Seuntjens Eve E Kernie Steven G SG Bukshpun Polina P Sherr Elliott H EH Huylebroeck Danny D Lu Q Richard QR
Neuron 20120201 4
Myelination by oligodendrocytes in the central nervous system (CNS) is essential for proper brain function, yet the molecular determinants that control this process remain poorly understood. The basic helix-loop-helix transcription factors Olig1 and Olig2 promote myelination, whereas bone morphogenetic protein (BMP) and Wnt/β-catenin signaling inhibit myelination. Here we show that these opposing regulators of myelination are functionally linked by the Olig1/2 common target Smad-interacting prot ...[more]