Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yang Yu
PROVIDER: E-GEOD-42454 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yu Yang Y Chen Ying Y Kim Bongwoo B Wang Haibo H Zhao Chuntao C He Xuelian X Liu Lei L Liu Wei W Wu Lai Man N LM Mao Meng M Chan Jonah R JR Wu Jiang J Lu Q Richard QR
Cell 20130101 1-2
Establishment of oligodendrocyte identity is crucial for subsequent events of myelination in the CNS. Here, we demonstrate that activation of ATP-dependent SWI/SNF chromatin-remodeling enzyme Smarca4/Brg1 at the differentiation onset is necessary and sufficient to initiate and promote oligodendrocyte lineage progression and maturation. Genome-wide multistage studies by ChIP-seq reveal that oligodendrocyte-lineage determination factor Olig2 functions as a prepatterning factor to direct Smarca4/Br ...[more]