Unknown,Transcriptomics,Genomics,Proteomics

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Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish


ABSTRACT: we report a transcriptome-wide comparative investigation between surface and cave species in Sinocyclocheilus. De novo transcriptome assemblies were performed on surface and cave species; then the Sinocyclocheilus contigs were annotated with Gene Ontology. RNA-Seq assays revealed reduced transcription of a series of visual phototransduction and retinal disease related genes in cave-dwelling species compared with surface species. Degeneration of the retina in Sinocyclocheilus cavefish might occur in a lens-independent way by the down-regulation of several transcriptional factors, which have direct roles in retina development and maintenance, such as crx, rorb and Wnt pathway members. Examination of 2 different eye samples in 2 Sinocyclocheilus species.

ORGANISM(S): Sinocyclocheilus anophthalmus

SUBMITTER: Fanwei Meng 

PROVIDER: E-GEOD-40446 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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