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ORNL 5wk Hr(n)/+ mice skin array

ABSTRACT: This array is spotted in house in order to survey the interested genes expressed mainly in skin with the selection of the clones from Research Genetics. Keywords: Genetic Mutant 5 week-old heterozygous Hr(n) mutant mice vs wild-type mice was used in the microarray. Four biological replicates were included from the same litter. Dye swapping was done to control dye-specific errors. The data was analyzed with ImaGene and GeneSight from BioDiscovery.

ORGANISM(S): Mus musculus

SUBMITTER: Yutao Liu

PROVIDER: E-GEOD-4053 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular basis for hair loss in mice carrying a novel nonsense mutation (Hrrh-R ) in the hairless gene (Hr).

Liu Y Y Sundberg J P JP Das S S Carpenter D D Cain K T KT Michaud E J EJ Voy B H BH

Veterinary pathology 20100101 1

Animal models carrying mutations in the hairless (Hr) gene provide a rich resource for study of hair follicle biology. A spontaneous mouse mutant with a phenotype strikingly similar to rhino mutants of Hr arose spontaneously in the mouse facility at Oak Ridge National Laboratory. Sequence analysis of Hr in these mutants uncovered a nonsense mutation in exon 12, designated as Hr(rh-R) (rhino, Oak Ridge). The mutation led to significant reduction in Hr mRNA levels, predicted to be due to nonsense- ...[more]

PMID: 20080498

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