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ORNL Hr(Rh-R) mouse cutaneous array

ABSTRACT: These data is from 10 day-old Hr(Rh-R)/Hr(Rh-R) vs Hr(Rh-R)/+ mice. Mouse 15k microarray from the Center for Applied Genomics was used to survey the gene expression. The data was acquired with ImaGene and processed with GeneSight from BioDiscovery. Keywords: Genetic mutants Three pairs of littermates from one liter, 10 day-old Hr(Rh-R)/Hr(Rh-R) vs Hr(Rh-R)/+ mice, were used for the hybridization. Dye-swapping was done for each pair of littermates.

ORGANISM(S): Mus musculus

SUBMITTER: Yutao Liu 

PROVIDER: E-GEOD-4055 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Molecular basis for hair loss in mice carrying a novel nonsense mutation (Hrrh-R ) in the hairless gene (Hr).

Liu Y Y   Sundberg J P JP   Das S S   Carpenter D D   Cain K T KT   Michaud E J EJ   Voy B H BH  

Veterinary pathology 20100101 1

Animal models carrying mutations in the hairless (Hr) gene provide a rich resource for study of hair follicle biology. A spontaneous mouse mutant with a phenotype strikingly similar to rhino mutants of Hr arose spontaneously in the mouse facility at Oak Ridge National Laboratory. Sequence analysis of Hr in these mutants uncovered a nonsense mutation in exon 12, designated as Hr(rh-R) (rhino, Oak Ridge). The mutation led to significant reduction in Hr mRNA levels, predicted to be due to nonsense-  ...[more]

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