Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Gunnar Cario
PROVIDER: E-GEOD-4057 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cario Gunnar G Stanulla Martin M Fine Bernard M BM Teuffel Oliver O Neuhoff Nils V NV Schrauder André A Flohr Thomas T Schäfer Beat W BW Bartram Claus R CR Welte Karl K Schlegelberger Brigitte B Schrappe Martin M
Blood 20040923 2
Treatment resistance, as indicated by the presence of high levels of minimal residual disease (MRD) after induction therapy and induction consolidation, is associated with a poor prognosis in childhood acute lymphoblastic leukemia (ALL). We hypothesized that treatment resistance is an intrinsic feature of ALL cells reflected in the gene expression pattern and that resistance to chemotherapy can be predicted before treatment. To test these hypotheses, gene expression signatures of ALL samples wit ...[more]