Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Elisabeth Nilsson
PROVIDER: E-GEOD-4063 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nilsson Elisabeth C EC Long Yun Chau YC Martinsson Sofia S Glund Stephan S Garcia-Roves Pablo P Svensson L Thomas LT Andersson Leif L Zierath Juleen R JR Mahlapuu Margit M
The Journal of biological chemistry 20060112 11
AMP-activated protein kinase (AMPK) is an evolutionarily conserved heterotrimer important for metabolic sensing in all eukaryotes. The muscle-specific isoform of the regulatory gamma-subunit of the kinase, AMPK gamma3, has an important role in glucose uptake, glycogen synthesis, and fat oxidation in white skeletal muscle, as previously demonstrated by physiological characterization of AMPK gamma3 mutant (R225Q) transgenic (TgPrkag3(225Q)) and gamma3 knock-out (Prkag3(-/-)) mice. We determined AM ...[more]