Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of skeletal muscle in AMPK gamma3 mutant (R225Q) transgenic mice and wild type littermates


ABSTRACT: Analysis of AMPK gamma3-dependent transcriptional responses by analyzing global gene expression in the white portion of the gastrocnemius muscle in AMPK gamma3 mutant (R225Q) transgenic mice and corresponding wild type littermates.

ORGANISM(S): Mus musculus

SUBMITTER: Elisabeth Nilsson 

PROVIDER: E-GEOD-4065 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice.

Nilsson Elisabeth C EC   Long Yun Chau YC   Martinsson Sofia S   Glund Stephan S   Garcia-Roves Pablo P   Svensson L Thomas LT   Andersson Leif L   Zierath Juleen R JR   Mahlapuu Margit M  

The Journal of biological chemistry 20060112 11


AMP-activated protein kinase (AMPK) is an evolutionarily conserved heterotrimer important for metabolic sensing in all eukaryotes. The muscle-specific isoform of the regulatory gamma-subunit of the kinase, AMPK gamma3, has an important role in glucose uptake, glycogen synthesis, and fat oxidation in white skeletal muscle, as previously demonstrated by physiological characterization of AMPK gamma3 mutant (R225Q) transgenic (TgPrkag3(225Q)) and gamma3 knock-out (Prkag3(-/-)) mice. We determined AM  ...[more]

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