Ontology highlight
ABSTRACT:
ORGANISM(S): Danio rerio
SUBMITTER: Weiling Zheng
PROVIDER: E-GEOD-40745 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Li Zhen Z Zheng Weiling W Wang Zhengyuan Z Zeng Zhiqiang Z Zhan Huiqing H Li Caixia C Zhou Li L Yan Chuan C Spitsbergen Jan M JM Gong Zhiyuan Z
Disease models & mechanisms 20121004 2
Myc is a pleiotropic transcription factor that is involved in many cellular activities relevant to carcinogenesis, including hepatocarcinogenesis. The zebrafish has been increasingly used to model human diseases and it is particularly valuable in helping to identify common and conserved molecular mechanisms in vertebrates. Here we generated a liver tumor model in transgenic zebrafish by liver-specific expression of mouse Myc using a Tet-On system. Dosage-dependent induction of Myc expression spe ...[more]