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Transcriptomic analyses of Kras induced zebrafish liver cancer

ABSTRACT: The kras transgenic line was generated by using a mifepristone-inducible transgenic system in combination with a Cre-loxP system. Most of the induced transgenic fish developed hepatocellular carcinoma at 6 month-post-induction. Transcriptome profiling of Kras tumor sample (6T1 and 6T2) and control samples (6M1 and 6M2) were generated by deep sequencing, using 3' RNA-SAGE on SOLiD system

ORGANISM(S): Danio rerio

SUBMITTER: Weiling Zheng

PROVIDER: E-GEOD-53630 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma.

Zheng Weiling W Li Zhen Z Nguyen Anh Tuan AT Li Caixia C Emelyanov Alexander A Gong Zhiyuan Z

PloS one 20140314 3

Previously three oncogene transgenic zebrafish lines with inducible expression of xmrk, kras or Myc in the liver have been generated and these transgenic lines develop oncogene-addicted liver tumors upon chemical induction. In the current study, comparative transcriptomic approaches were used to examine the correlation of the three induced transgenic liver cancers with human liver cancers. RNA profiles from the three zebrafish tumors indicated relatively small overlaps of significantly deregulat ...[more]

PMID: 24633177

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