Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Tsuyoshi Fukushima
PROVIDER: E-GEOD-40856 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hoshiko Shinri S Kawaguchi Makiko M Fukushima Tsuyoshi T Haruyama Yukihiro Y Yorita Kenji K Tanaka Hiroyuki H Seiki Motoharu M Inatsu Haruhiko H Kitamura Kazuo K Kataoka Hiroaki H
Cancer research 20130227 8
Hepatocyte growth factor activator inhibitor type 1 (HAI-1/SPINT1) is a membrane-bound serine protease inhibitor expressed on the surface of epithelial cells. Although HAI-1/SPINT1 is abundantly expressed in the intestinal epithelium, its role in intestinal tumorigenesis is not known. In this study, we investigated the role of Hai-1/Spint1 in intestinal tumorigenesis using mouse models. The membranous Hai-1/Spint1 immunoreactivity was decreased in murine Apc(Min/+) tumors and also in carcinogen ...[more]