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Transcription profiling by array of Apc-deficient mouse small intestinal epithelium upon Msx1 depletion.

ABSTRACT: The first step in the development of human colorectal cancer is the aberrant hyperactivation of the Wnt signaling pathway, predominantly caused by inactivating mutations in the adenomatous polyposis coli (Apc) gene encoding an essential tumor suppressor. The gene encoding transcriptional factor msh homeobox 1 (Msx1) displayed robust upregulation upon Apc inactivation in intestinal epithelium isolated in mice harboring the conditional allele of the Apc gene. To identify the gene signature in the small intestine upon Msx1 depletion, small intestinal epithelium from mice harboring conditional alleles of Apc and Msx1 was isolated and the gene expression profile was compared with control mice harboring the conditional allele of Apc only.

ORGANISM(S): Mus musculus

SUBMITTER: Monika Horazna

PROVIDER: E-MTAB-6930 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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