Sir-2.1 low copy transgenic
Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Min Jiang
PROVIDER: E-GEOD-4095 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.
Viswanathan Mohan M Kim Stuart K SK Berdichevsky Ala A Guarente Leonard L
Developmental cell 20051101 5
C. elegans SIR-2.1, a member of the Sir-2 family of NAD(+)-dependent protein deacetylases, has been shown to regulate nematode aging via the insulin/IGF pathway transcription factor daf-16. Treatment of C. elegans with the small molecule resveratrol, however, extends life span in a manner fully dependent upon sir-2.1, but independent of daf-16. Microarray analysis of worms treated with resveratrol demonstrates the transcriptional induction of a family of genes encoding prion-like glutamine/aspar ...[more]
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