Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Quaking is a global regulator of muscle-specific alternative splicing in vertebrates


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Manny Ares 

PROVIDER: E-GEOD-40962 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiation.

Hall Megan P MP   Nagel Roland J RJ   Fagg W Samuel WS   Shiue Lily L   Cline Melissa S MS   Perriman Rhonda J RJ   Donohue John Paul JP   Ares Manuel M  

RNA (New York, N.Y.) 20130322 5


Alternative splicing contributes to muscle development, but a complete set of muscle-splicing factors and their combinatorial interactions are unknown. Previous work identified ACUAA ("STAR" motif) as an enriched intron sequence near muscle-specific alternative exons such as Capzb exon 9. Mass spectrometry of myoblast proteins selected by the Capzb exon 9 intron via RNA affinity chromatography identifies Quaking (QK), a protein known to regulate mRNA function through ACUAA motifs in 3' UTRs. We  ...[more]

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