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Expression data from Fbxl10 overexpressing 3T3-L1 cells

ABSTRACT: Target genes of Fbxl10 during 3T3-L1 adipogenesis was analyzed 3T3-L1 cells overexpressing Fbxl10 using retrovirus system containing LTR promoter were differentiated and RNA was extracted at day 2 of differentiation

ORGANISM(S): Mus musculus

SUBMITTER: Takeshi Inagaki

PROVIDER: E-GEOD-64154 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.

Inagaki Takeshi T Iwasaki Satoshi S Matsumura Yoshihiro Y Kawamura Takeshi T Tanaka Toshiya T Abe Yohei Y Yamasaki Ayumu A Tsurutani Yuya Y Yoshida Ayano A Chikaoka Yoko Y Nakamura Kanako K Magoori Kenta K Nakaki Ryo R Osborne Timothy F TF Fukami Kiyoko K Aburatani Hiroyuki H Kodama Tatsuhiko T Sakai Juro J

The Journal of biological chemistry 20141222 7

Polycomb repressive complex 1 (PRC1) plays an essential role in the epigenetic repression of gene expression during development and cellular differentiation via multiple effector mechanisms, including ubiquitination of H2A and chromatin compaction. However, whether it regulates the stepwise progression of adipogenesis is unknown. Here, we show that FBXL10/KDM2B is an anti-adipogenic factor that is up-regulated during the early phase of 3T3-L1 preadipocyte differentiation and in adipose tissue in ...[more]

PMID: 25533466

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Genome-wide RING1B binding in Fbxl10 overexpressing 3T3-L1 cells at day 2 of differentiation

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Expression data from Fbxl10 overexpressing 3T3-L1 cells

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