Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Thorsten Mueller
PROVIDER: E-GEOD-4097 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Müller Thorsten T Concannon Caoimhin G CG Ward Manus W MW Walsh Ciara M CM Tirniceriu Anca L AL Tribl Florian F Kögel Donat D Prehn Jochen H M JH Egensperger Rupert R
Molecular biology of the cell 20061108 1
Amyloidogenic processing of the amyloid precursor protein (APP) results in the generation of beta-amyloid, the main constituent of Alzheimer plaques, and the APP intracellular domain (AICD). Recently, it has been demonstrated that AICD has transactivation potential; however, the targets of AICD-dependent gene regulation and hence the physiological role of AICD remain largely unknown. We analyzed transcriptome changes during AICD-dependent gene regulation by using a human neural cell culture syst ...[more]