Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human SHEP-SF cells expressing AICD and Fe65


ABSTRACT: The amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimerâ??s disease (AD). Processing of APP by β- and γ-secretase activities results in the production of Ã?-amyloid (AÃ?), the main constituent of Alzheimer plaques, but also in the generation of the APP intracellular domain (AICD). Recently, it has been demonstrated that AICD has transactivation potential, however, the targets of AICD dependent gene regulation and hence the physiological role of AICD remain largely unknown. In this work we analysed transcriptome changes during AICD dependent gene regulation using a human neural cell culture system inducible for expression of AICD, its co-activator Fe65, or the combination of both. Induction of AICD was associated with increased expression of genes with known function in the organization and dynamics of the actin cytoskeleton as well as genes involved in the regulation of apoptosis.

ORGANISM(S): Homo sapiens

SUBMITTER: Thorsten Mueller 

PROVIDER: E-GEOD-4097 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD).

Müller Thorsten T   Concannon Caoimhin G CG   Ward Manus W MW   Walsh Ciara M CM   Tirniceriu Anca L AL   Tribl Florian F   Kögel Donat D   Prehn Jochen H M JH   Egensperger Rupert R  

Molecular biology of the cell 20061108 1


Amyloidogenic processing of the amyloid precursor protein (APP) results in the generation of beta-amyloid, the main constituent of Alzheimer plaques, and the APP intracellular domain (AICD). Recently, it has been demonstrated that AICD has transactivation potential; however, the targets of AICD-dependent gene regulation and hence the physiological role of AICD remain largely unknown. We analyzed transcriptome changes during AICD-dependent gene regulation by using a human neural cell culture syst  ...[more]

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