Unknown,Transcriptomics,Genomics,Proteomics

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Follicular Lymphoma Array CGH


ABSTRACT: We run aCGH of 64 FL samples and we looked for recurrent chromosomal alterations. we analyzed 64 FL samples by aCGH

ORGANISM(S): Homo sapiens

SUBMITTER: Elisa Oricchio 

PROVIDER: E-GEOD-40989 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Insights into cancer genetics can lead to therapeutic opportunities. By cross-referencing chromosomal changes with an unbiased genetic screen we identify the ephrin receptor A7 (EPHA7) as a tumor suppressor in follicular lymphoma (FL). EPHA7 is a target of 6q deletions and inactivated in 72% of FLs. Knockdown of EPHA7 drives lymphoma development in a murine FL model. In analogy to its physiological function in brain development, a soluble splice variant of EPHA7 (EPHA7(TR)) interferes with anoth  ...[more]

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