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Genome-wide map of chromatin states and global transcriptome profiling in SETD2 wild type and mutant cells

ABSTRACT: We looked at the distribution of the histone mark H3K36me3 in wild type 293T and SETD2 deleted 293T (KO) cells. We also looked at the H3K36me3 profile after rescuing the KO cells with recombinant SETD2 constructs; FL (full length), N3 (1404-2564) and N3ΔSRI/N3woSRI (1404-2468). Furthermore, we performed RNA-Seq of cells expressing the wild type or mutant/recombinant copy of SETD2 to compare their global transcriptome profile.

ORGANISM(S): Homo sapiens

PROVIDER: GSE147752 | GEO | 2021/03/25

REPOSITORIES: GEO

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