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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of ischemia-reperfused Rattus norvegicus heart tissue samples

ABSTRACT: Rats underwent surgery for LAD ligation for 30 min followed by reperfusion. Heart ventricles were collected 2d or 7d after reperfusion. Experiment Overall Design: rats were divided in following groups that underwent LAD occlusion or not (SHAM): Experiment Overall Design: 1. 7d-IR (n=3) Experiment Overall Design: 2. 7d-sham (n=3) Experiment Overall Design: 3. 2d-IR (n=3) Experiment Overall Design: 4. 7d-sham (n=3)

ORGANISM(S): Rattus norvegicus

DISEASE(S): normal

SUBMITTER: Sashwati Roy

PROVIDER: E-GEOD-4105 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix.

Roy Sashwati S Khanna Savita S Kuhn Donald E DE Rink Cameron C Williams Willis T WT Zweier Jay L JL Sen Chandan K CK

Physiological genomics 20060322 3

cDNA microarray analysis was performed to screen 15,000 genes and expressed sequence tags (ESTs) to identify changes in the ischemia-reperfused (I-R) rat myocardial transcriptome in the early (day 2) and late (day 7) inflammatory phases of acute myocardial infarction. Lists of candidate genes that were affected by I-R transiently (2 or 7 days only) or on a more sustained basis (2 and 7 days) were derived. The candidate genes represented three major functional categories: extracellular matrix, ap ...[more]

PMID: 16554547

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Rat LAD IR study

Project description:Rats underwent surgery for LAD ligation for 30 min followed by reperfusion. Heart ventricles were collected 2d or 7d after reperfusion. Keywords: rat heart ventricles, LAD - left anterior descending coronary artery, IR - ischemia-reperfusion

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Potential Target Genes of MicroRNA-21 In Ischemia-Reperfusion Injury Of The Gracilis Muscle In Rats

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2010-05-07 | E-GEOD-21406 | biostudies-arrayexpress

Multi-omic map revealed PPARα activation protecting against myocardial ischemia/reperfusion injury by maintaining cardiac metabolic homeostasis [bulk RNA-seq]

Project description:The rats were subjected to left anterior descending (LAD) coronary artery ligation for 1 hour, 6 hours (MI1h and MI6h) and 24 hours (MI24h) along with Sham controls (Sham), and 1-hour, 6-hour ischemia followed by reperfusion (MI1h/R and MI6h/R, mimicking early time reperfusion (ETR) and late time reperfusion (LTR), respectively) followed by heart tissue collection 24 hours post MI to mimic the MI/R injury in AMI patients and pretreatment with FDA-approved PPARα agonist fenofibrate for each group.

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CXCR1 and Its Downstream NF-κB Inflammation Signaling Pathway as a Key Target of Guanxinning Injection for Myocardial Ischemia/reperfusion Injury

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Transcription profiling of mouse lung to investigate effects of ischemia reperfusion injury or nephrectomy

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2008-06-15 | E-GEOD-6730 | biostudies-arrayexpress

Transcription profiling of rat heart after ischaemia reperfusion injury and then treatment with saline, urocortin I, urocortin II or tempol

Project description:The transcriptional effects of urocortin I, urocortin II and tempol were compared to saline treatment in a rat model of in vivo coronary artery occlusion model of ischaemia/reperfusion injury of 25 min ischaemia and 2 hr reperfusion. <br>The treatment groups were as follows (i) sham operation or LAD occlusion with infusion of (ii) saline, (iii) 15 ?g/kg Ucn I, (iv) 15 ?g/kg Ucn II and (v) 100 mg/kg tempo infused just prior to reperfusionl.<br>Following 2 hr reperfusion the left ventricle was removed, snap frozen, followed by RNA extraction.

2009-03-25 | E-MEXP-2098 | biostudies-arrayexpress

Mapping Ischemia Reperfusion Inflammatory Responses in Human Lung Transplantation at Single-Cell Resolution

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