Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression of the colonic epithelial cells in CRB mice fed with HFD and LFD


ABSTRACT: To elucidate the mechamisms of colonic Treg cell induction by microbial metabolite(s), chroloform-resistant bacteria (CRB)-associated mice was developed and given low-fiber diet (LFD) and high-fiber diet (HFD). The colonic epithelial cells were isolated and gene expression profiles were analyzed by GeneChip. Clonic epithelial cells in CRB mice fed with HFD and LFD were isolated for RNA extraction and hybridization on Affymetrix microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Shinji Fukuda 

PROVIDER: E-GEOD-41104 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. However, the molecular mechanisms by which commensal microbes induce colonic Treg cells have been unclear. Here we show that a large bowel microbial fermentation product, butyrate, induce  ...[more]

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