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Gene expression profile of the liver metastatic tumor tissue in HFD-fed and LFD-fed mice [RNA-seq]

ABSTRACT: To investigate the effect of diet and Yap KD on liver matastasis, we injected MC38 cells in LFD-fed or HFD-fed mice, and MC38 with shCon or shRNA for Yap (shYap1) in HFD-fed mice We then performed gene expression profiling analysis using data obtained from RNA-seq of these 4 different conditions

ORGANISM(S): Mus musculus

PROVIDER: GSE227913 | GEO | 2023/05/11

REPOSITORIES: GEO

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Gene expression profile at single cell level of immune cells from the liver metasized tumor tissue [scRNA-seq]

Project description:To investigate the effect of diet and Yap KD on liver matastasis, we injected MC38 cells in LFD-fed or HFD-fed mice, and MC38 with shCon or shRNA for Yap (shYap1) in HFD-fed mice We then performed gene expression profiling analysis in various cell types using data obtained from single cell RNA-seq of these 4 different conditions

2023-05-11 | GSE227914 | GEO

Gene expression of the colonic epithelial cells in CRB mice fed with HFD and LFD

Project description:To elucidate the mechamisms of colonic Treg cell induction by microbial metabolite(s), chroloform-resistant bacteria (CRB)-associated mice was developed and given low-fiber diet (LFD) and high-fiber diet (HFD). The colonic epithelial cells were isolated and gene expression profiles were analyzed by GeneChip. Clonic epithelial cells in CRB mice fed with HFD and LFD were isolated for RNA extraction and hybridization on Affymetrix microarrays.

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HFD versus LFD [RNA-seq]

Project description:HFD versus LFD [RNA-seq]

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Gene expression of the colonic epithelial cells in CRB mice fed with HFD and LFD

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Spleen proteomics data from high fat diet fed mice

Project description:The composition of the diet affects many processes in the body, including body weight and endocrine system. We have previously shown that dietary fat also affects the immune system. Mice fed high fat diet rich in polyunsaturated fatty acids survive S. aureus infection to a much greater extent than mice fed high fat diet rich in saturated fatty acids. Here we present data regarding the dietary effects on protein expression in spleen from mice fed three different diets, I) low fat/chow diet (LFD, n=4), II) high fat diet rich in saturated fatty acids (HFD-S, n=4) and III) high fat diet rich in polyunsaturated fatty acids (HFD-P, n=4). We performed mass spectrophotometry based quantitative proteomics analysis of isolated spleen by implementing the isobaric tags for relative and absolute quantification (iTRAQ) approach. Mass spectrometry data were analysed using Proteome Discoverer 2.4 software using the search engine mascot against Mus musculus in SwissProt. 924 proteins are identified in all sets (n=4) for different dietary effects taken for statistical analysis using Qlucore Omics Explorer software. Only 20 proteins were found to be differentially expressed with a cut-off value of false discovery rate < 0.1 (q-value) when comparing HFD-S and HFD-P but no differentially expressed proteins were found when LFD was compared with HFD-P or HFD-S. We identified a subset of proteins that showed an inverse expression pattern between two high fat diets. These differentially expressed proteins were further classified by gene ontology for their role in biological processes and molecular functions.

2020-08-06 | PXD020365 | Pride

Differential gene expression in HFD-fed mouse liver

Project description:Hepatic expression of genes in chow-fed and HFD-fed mice were compared.

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Genome-wide expression profile of livers from mice fed HFD,SO-HFD or Viv chow [RNAseq]

Project description:Purpose: Aim of the study is to identify changes in hepatic gene expression induced by either a 40kcal% coconut oil rich high fat diet (HFD), a 40kcal% soybean oil plus coconut oil high fat diet (SO-HFD) or a low fat vivarium chow diet (Viv). Methods: Livers from mice that had been fed one of the above mentioned diets for 35 weeks, were used to make cDNA libraries that were then sent for deep sequencing, using the Illumina TruSeq RNA. Result: Many genes involved in metabolism, lipid binding, transport and storage and many Cyp genes are dysregulated in the two high fat diets as compared to Viv HFDs in SO-HFD mice. Comparing the two HFDs shows more metabolism and disease related genes dysregulated in SO-HFD vs HFD. Conclusion: A diet high in soybean oil may be more detrimental to metabolic health than a diet high in saturated fats. cDNA isolated from livers from mice fed HFD, SO-HFD or Viv for 35 weeks, were 50bp pair-ended sequenced in triplicate using Illumina TruSeq RNA Sample Prep v2 Kit.

2015-08-28 | E-GEOD-68360 | biostudies-arrayexpress

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Gene expression profiling of adipocyte and stromal vascular cells from adipose tissue in lean, obese and formerly obese mice

Project description:To investigate the transcriptional profiles of adipocytes and stromal vascular cells from mouse visceral adipose tissue(vWAT) in lean (Low fat diet, LFD fed), obese (high fat diet, HFD fed) and formerly obese (diet switch (SW) from 9 weeks HFD, to 3 weeks LFD) to induce weight loss.

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