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Expression data of lungs of mice infected with two highly pathogenic avian influenza viruses

ABSTRACT: We isolated two highly pathogenic H5N1 avian influenza viruses (AIVs) (CK10 and GS10) with similar genetic background but greatly differ in pathogencity in mice. CK10 is highly pathogenic in mice, whereas GS10 is nonpathogenic. However, the host mechanism of this differecne in pathogenicity is unclear. We used microarray analysis to evaluate the global transcriptional response in the lung of mice infected with CK10 or GS10. Six-week-old female BALB/c mice were inoculated with CK10 or GS10 or mock-infected. At day 1 post infection, lungs were isolated from three mice per group for RNA extraction and hybridization on Agilent microarrays. Samples were named as follows: CK10 (CK10_1_NS,CK10_2_NS,CK10_3_NS) GS10 (GS10_1_NS,GS10_2_NS, GS10_3_NS) control (C1_NS, C2_NS, C3_NS).

ORGANISM(S): Mus musculus

SUBMITTER: Jiao Hu

PROVIDER: E-GEOD-41126 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data of lungs of mice infected with two highly pathogenic avian influenza viruses

Project description:We isolated two highly pathogenic H5N1 avian influenza viruses (AIVs) (CK10 and GS10) with similar genetic background but greatly differ in pathogencity in mice. CK10 is highly pathogenic in mice, whereas GS10 is nonpathogenic. However, the host mechanism of this differecne in pathogenicity is unclear. We used microarray analysis to evaluate the global transcriptional response in the lung of mice infected with CK10 or GS10.

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Gene Expression Analysis of Host Immune Responses in rhesus macaques infected with SIVmac239 or deglycosylated live-attenuated SIV

Project description:To find the differences in innate immune response between nonpathogenic and pathogenic SIV infection, we examined transcriptome in PBMCs from macaques infected with pathogenic or nonpathogenic SIV.

2014-10-10 | GSE62209 | GEO

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