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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse tumoros from cdc25a over-expressing animals - (MMTV-cdc25a;MMTV-neu and MMTV-neu

ABSTRACT: CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumorigenesis induced by expression of ras or neu. CDC25A- overexpressing tumors display aggressiveness and genomic instability with changes in fragile chromosomal regions, including the region orthologous to human 1p32-36. Experiment Overall Design: Tumors from two mice from each of two conditions (MMTV-cdc25a;MMTV-neu and MMTV-neu) were analyzed in a dye swap experiment. A total of four hybridizations were performed.

ORGANISM(S): Mus musculus

SUBMITTER: Eleftherios Papoutsakis

PROVIDER: E-GEOD-4114 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability.

Ray Dipankar D Terao Yasuhisa Y Fuhrken Peter G PG Ma Zhi-Qing ZQ DeMayo Francesco J FJ Christov Konstantin K Heerema Nyla A NA Franks Roberta R Tsai Sophia Y SY Papoutsakis Eleftherios T ET Kiyokawa Hiroaki H

Cancer research 20070201 3

Checkpoint pathways help cells maintain genomic integrity, delaying cell cycle progression in response to various risks of fidelity, such as genotoxic stresses, compromised DNA replication, and impaired spindle control. Cancer cells frequently exhibit genomic instability, and recent studies showed that checkpoint pathways are likely to serve as a tumor-suppressive barrier in vivo. The cell cycle-promoting phosphatase CDC25A is an activator of cyclin-dependent kinases and one of the downstream ta ...[more]

PMID: 17283130

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