Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Eleftherios Papoutsakis
PROVIDER: E-GEOD-4767 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer research 20070201 3
Checkpoint pathways help cells maintain genomic integrity, delaying cell cycle progression in response to various risks of fidelity, such as genotoxic stresses, compromised DNA replication, and impaired spindle control. Cancer cells frequently exhibit genomic instability, and recent studies showed that checkpoint pathways are likely to serve as a tumor-suppressive barrier in vivo. The cell cycle-promoting phosphatase CDC25A is an activator of cyclin-dependent kinases and one of the downstream ta ...[more]