Dataset Information
Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 1)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Sangjun Lee
PROVIDER: E-GEOD-41194 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Differentially expressed genes regulating the progression of ductal carcinoma in situ to invasive breast cancer.
Cancer research 20120702 17
Molecular mechanisms mediating the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer remain largely unknown. We used gene expression profiling of human DCIS (n = 53) and invasive breast cancer (n = 51) to discover uniquely expressed genes that may also regulate progression. There were 470 total differentially expressed genes (≥2-fold; P < 0.05). Elevated expression of genes involved in synthesis and organization of extracellular matrix was particularly prominent in the epi ...[more]
