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Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 4 stroma)

ABSTRACT: We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE41198 | GEO | 2012/09/29

SECONDARY ACCESSION(S): PRJNA176238

REPOSITORIES: GEO

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Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 4 stroma)

Project description:We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression. RNA from human samples were extracted, purified, amplified, and evaluated for gene expression using Affymetrix U133-X3P gene expression arrays.

2012-09-29 | E-GEOD-41198 | biostudies-arrayexpress

Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 3)

Project description:We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

2012-09-29 | GSE41197 | GEO

Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 1)

Project description:We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

2012-09-29 | GSE41194 | GEO

Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 2)

Project description:We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

2012-09-29 | GSE41196 | GEO

Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 4 Epithelial)

Project description:We used gene expression profiling of human DCIS and IBC to discover uniquely expressed genes that may also regulate progression.

2012-09-29 | GSE41227 | GEO

Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 1)

2012-09-29 | E-GEOD-41194 | biostudies-arrayexpress

Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 3)

2012-09-29 | E-GEOD-41197 | biostudies-arrayexpress

Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 2)

2012-09-29 | E-GEOD-41196 | biostudies-arrayexpress

Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 4 Epithelial)

2012-09-29 | E-GEOD-41227 | biostudies-arrayexpress

Progression of ductal carcinoma in situ to invasive breast cancer

Project description:Ductal carcinoma in situ (DCIS) is a precursor lesion that can give rise to invasive breast cancer (IBC). It has been proposed that both the nature of the lesion and the tumor microenvironment play key roles in progression to IBC. Here, laser capture microdissected tissue samples from epithelium and stroma in normal breast, pure DCIS, and pure IBC were employed to define key gene expression profiles associated with disease progression. Tumor and matching stroma were profiled for 9 DCIS patients, 10 IBC patients, and 3 normal breast. Differential gene expression was evaluated for paired normal stroma versus normal epitelium samples, paired DCIS stroma versus DCIS epitelium samples, paired IBC stroma versus IBC epitelium, IBC stroma versus DCIS stroma, and IBC epithelium versus DCIS epithelium.

2012-03-31 | E-GEOD-33692 | biostudies-arrayexpress

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