Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE41130: Expression profiling of Low-Risk Myelodysplastic Syndromes (MDSs) GSE41215: Methylation profiling of Low-Risk Myelodysplastic Syndromes (MDSs) Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Javier De Las Rivas 

PROVIDER: E-GEOD-41216 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.

del Rey M M   O'Hagan K K   Dellett M M   Aibar S S   Colyer H A A HA   Alonso M E ME   Díez-Campelo M M   Armstrong R N RN   Sharpe D J DJ   Gutiérrez N C NC   García J L JL   De Las Rivas J J   Mills K I KI   Hernández-Rivas J M JM  

Leukemia 20120831 3


Gene expression profiling signatures may be used to classify the subtypes of Myelodysplastic syndrome (MDS) patients. However, there are few reports on the global methylation status in MDS. The integration of genome-wide epigenetic regulatory marks with gene expression levels would provide additional information regarding the biological differences between MDS and healthy controls. Gene expression and methylation status were measured using high-density microarrays. A total of 552 differentially  ...[more]

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