Unknown,Transcriptomics,Genomics,Proteomics

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Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE41194: Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 1) GSE41196: Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 2) GSE41197: Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 3) GSE41198: Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 4 stroma) GSE41227: Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer (Group 4 Epithelial) Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Sangjun Lee 

PROVIDER: E-GEOD-41228 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differentially expressed genes regulating the progression of ductal carcinoma in situ to invasive breast cancer.

Lee Sangjun S   Stewart Sheila S   Nagtegaal Iris I   Luo Jingqin J   Wu Yun Y   Colditz Graham G   Medina Dan D   Allred D Craig DC  

Cancer research 20120702 17

Molecular mechanisms mediating the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer remain largely unknown. We used gene expression profiling of human DCIS (n = 53) and invasive breast cancer (n = 51) to discover uniquely expressed genes that may also regulate progression. There were 470 total differentially expressed genes (≥2-fold; P < 0.05). Elevated expression of genes involved in synthesis and organization of extracellular matrix was particularly prominent in the epi  ...[more]

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