Unknown,Transcriptomics,Genomics,Proteomics

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Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes


ABSTRACT: We determined the occupancy of SUMO-1 on chromatin in HeLa cells by use of chromatin affinity purification coupled with next generation sequencing 18 samples examined in syncrhonized HeLa cells: Cells in G1, early S (S0)/mid (S3)/ late S phase (S6), and mitosis (M), triplicates for each sample. 1 ChIP-SUMO1 sample in S0, and 1 ChIP-IgG control

ORGANISM(S): Homo sapiens

SUBMITTER: Jeffrey Parvin 

PROVIDER: E-GEOD-41264 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes.

Liu Hui-wen HW   Zhang Jie J   Heine George F GF   Arora Mansi M   Gulcin Ozer Hatice H   Onti-Srinivasan Raghuram R   Huang Kun K   Parvin Jeffrey D JD  

Nucleic acids research 20120831 20


SUMOylation of transcription factors and chromatin proteins is in many cases a negative mark that recruits factors that repress gene expression. In this study, we determined the occupancy of Small Ubiquitin-like MOdifier (SUMO)-1 on chromatin in HeLa cells by use of chromatin affinity purification coupled with next-generation sequencing. We found SUMO-1 localization on chromatin was dynamic throughout the cell cycle. Surprisingly, we observed that from G1 through late S phase, but not during mit  ...[more]

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