Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jeffrey Parvin
PROVIDER: E-GEOD-41264 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Liu Hui-wen HW Zhang Jie J Heine George F GF Arora Mansi M Gulcin Ozer Hatice H Onti-Srinivasan Raghuram R Huang Kun K Parvin Jeffrey D JD
Nucleic acids research 20120831 20
SUMOylation of transcription factors and chromatin proteins is in many cases a negative mark that recruits factors that repress gene expression. In this study, we determined the occupancy of Small Ubiquitin-like MOdifier (SUMO)-1 on chromatin in HeLa cells by use of chromatin affinity purification coupled with next-generation sequencing. We found SUMO-1 localization on chromatin was dynamic throughout the cell cycle. Surprisingly, we observed that from G1 through late S phase, but not during mit ...[more]