Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Aly Khan
PROVIDER: E-GEOD-41288 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Loeb Gabriel B GB Khan Aly A AA Canner David D Hiatt Joseph B JB Shendure Jay J Darnell Robert B RB Leslie Christina S CS Rudensky Alexander Y AY
Molecular cell 20121108 5
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a transcriptome-wide identification of the endogenous targets of a single miRNA-miR-155-in a genetically controlled manner. We found that approximat ...[more]