Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: John Blair
PROVIDER: E-GEOD-41341 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yuen Ryan K C RK Chen Baosheng B Blair John D JD Robinson Wendy P WP Nelson D Michael DM
Epigenetics 20130111 2
The mechanisms by which the placenta adapts to exogenous stimuli to create a stable and healthy environment for the growing fetus are not well known. Low oxygen tension influences placental function, and is associated with preeclampsia, a condition displaying altered development of placental trophoblast. We hypothesized that oxygen tension affects villous trophoblast by modulation of gene expression through DNA methylation. We used the Infinium HumanMethylation450 BeadChip array to compare the D ...[more]