Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Cultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: John Blair 

PROVIDER: E-GEOD-41341 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hypoxia alters the epigenetic profile in cultured human placental trophoblasts.

Yuen Ryan K C RK   Chen Baosheng B   Blair John D JD   Robinson Wendy P WP   Nelson D Michael DM  

Epigenetics 20130111 2


The mechanisms by which the placenta adapts to exogenous stimuli to create a stable and healthy environment for the growing fetus are not well known. Low oxygen tension influences placental function, and is associated with preeclampsia, a condition displaying altered development of placental trophoblast. We hypothesized that oxygen tension affects villous trophoblast by modulation of gene expression through DNA methylation. We used the Infinium HumanMethylation450 BeadChip array to compare the D  ...[more]

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