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Choice of infection or immunity: microarrays analysis of the mechanism of CpG DNA enhancing the immune response on BMDCs pulsed with H9N2 AIV

ABSTRACT: Dendritic cells (DCs), professional antigen presenting cells, have demonstrated effective in controlling the initial of innate immune and enhancing immune response of vaccination, also proved that adjuvant CpG could improve the performance of immune system.Although exist many studies concerning the downstream response of DCs pulsed with CpG, rarely research gaze the interaction of DCs co-stimulated with CpG/H9N2 or CpG/inactivated H9N2 To explore the underlying molecular basis, we compared different stimulated mouse DCs with systemic approach microarrays The cultured mouse BMDCs were randomly divided into 6 groups (1: control DCs group, 2:CpG stimulated group, 3: H9N2 stimulated group, 4: CpG/H9N2 co-stimulated group, 5: inactivated H9N2 stimulated group, 6: CpG/inactivated H9N2 co-stimulated group). we used microarray to reveal striking transcriptome differences of different stimulated DCs.

ORGANISM(S): Mus musculus

SUBMITTER: Jian Lin

PROVIDER: E-GEOD-41454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Enhanced immune response of BMDCs pulsed with H9N2 AIV and CpG

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2012-10-11 | GSE41454 | GEO

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