Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Abbie Saunders
PROVIDER: E-GEOD-41611 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Saunders Abbie A Core Leighton J LJ Sutcliffe Catherine C Lis John T JT Ashe Hilary L HL
Genes & development 20130501 10
Cascades of zygotic gene expression pattern the anterior-posterior (AP) and dorsal-ventral (DV) axes of the early Drosophila embryo. Here, we used the global run-on sequencing assay (GRO-seq) to map the genome-wide RNA polymerase distribution during early Drosophila embryogenesis, thus providing insights into how genes are regulated. We identify widespread promoter-proximal pausing yet show that the presence of paused polymerase does not necessarily equate to direct regulation through pause rele ...[more]