Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of whole Drosophila brains fron animals exposed to sleep deprivation


ABSTRACT: Analysis of brain of Canton-S females deprived of sleep by perturbations during their normal sleep period. Perturbation effect also assessed during their active period to control for its effect during sleep deprivation. Results suggest processes altered during prolonged wakefulness and during sleep.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: John Zimmerman 

PROVIDER: E-GEOD-4174 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Multiple mechanisms limit the duration of wakefulness in Drosophila brain.

Zimmerman John E JE   Rizzo Wendy W   Shockley Keith R KR   Raizen David M DM   Naidoo Nirinjini N   Mackiewicz Miroslaw M   Churchill Gary A GA   Pack Allan I AI  

Physiological genomics 20060905 3


The functions of sleep and what controls it remain unanswered biological questions. According to the two-process model, a circadian process and a homeostatic process interact to regulate sleep. While progress has been made in understanding the molecular and cellular functions of the circadian process, the mechanisms of the homeostatic process remain undiscovered. We use the recently established sleep model system organism Drosophila melanogaster to examine dynamic changes in gene expression duri  ...[more]

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