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Gene expression profiles in bone marrow of human gastric adenocarcinoma at stage III and stage IV

ABSTRACT: A secreted factor in bone marrow associated with metastatic gastric cancer was indentified through expression profiling in bone marrow of stage III and stage IV gastric adenocarcinoma. In the study presented here, bone marrow samples from patients with stage III or stage IV gastric adenocarcinoma were used to acquire expression profiles.

ORGANISM(S): Homo sapiens

SUBMITTER: Satoshi Kondo

PROVIDER: E-GEOD-41801 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression of bone morphogenic protein 8B in the primary site, peripheral blood and bone marrow of patients with gastric cancer.

Mima Kosuke K Fukagawa Takeo T Kurashige Junji J Takano Yuki Y Uchi Ryutaro R Ueo Hiroki H Matsumura Tae T Ishibashi Masahisa M Sawada Genta G Takahashi Yusuke Y Akiyoshi Sayuri S Eguchi Hidetoshi H Sudo Tomoya T Sugimachi Keishi K Watanabe Masayuki M Ishii Hideshi H Mori Masaki M Baba Hideo H Sasako Mitsuru M Mimori Koshi K

Oncology letters 20130612 2

The prognosis for individuals that are diagnosed with gastric cancer remains poor due to the high frequency of metastatic disease. In response to tumor-derived secreted factors, the bone marrow generates a suitable microenvironment for the development of metastasis. However, it is largely unknown whether secreted factors in bone marrow associated with metastatic disease of patients with gastric cancer are present. Secreted factors from the bone marrow of patients with metastatic gastric cancer w ...[more]

PMID: 24137334

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